Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(±)-1-Benzyl-4-(4-fluoro-phenyl)-3-hydroxymethyl-1,2,3,6-tetrahydro-pyridine, salt with benzenesulfonic acid
EC Number:
606-458-3
Cas Number:
201855-55-2
Molecular formula:
C19H20FNO C7H8O3S
IUPAC Name:
(±)-1-Benzyl-4-(4-fluoro-phenyl)-3-hydroxymethyl-1,2,3,6-tetrahydro-pyridine, salt with benzenesulfonic acid
Test material form:
solid: crystalline

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
18.8 mg/L
Nominal / measured:
estimated
Remarks on result:
other: Database: Aquatic Japan MoE

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that raceme hydroxy-methyl-tetrahydropyridine-tosilate is hazardous to the aquatic invertebrates (Daphnia magna). The result meets the requirement of Aquatic Acute Category 3.