Registration Dossier
Registration Dossier
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EC number: 606-457-8 | CAS number: 201855-54-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- In silico
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-benzyl-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine, salt with p-toluenesulfonic acid
- EC Number:
- 606-457-8
- Cas Number:
- 201855-54-1
- Molecular formula:
- C18H17FN*C7H8O3S
- IUPAC Name:
- 1-benzyl-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine, salt with p-toluenesulfonic acid
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Primal Irritation Index
- Score:
- 3.67
- Remarks on result:
- other: Database: Skin irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that tetrahydro-pyridine-tosilate is irritating to skin. The result meets the requirement of Hazard Category 2.
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