Registration Dossier
Registration Dossier
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EC number: 255-037-7 | CAS number: 40690-89-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[[2-(acetyloxy)ethyl][4-[(4-nitrophenyl)azo]phenyl]amino]propiononitrile
- EC Number:
- 269-950-3
- EC Name:
- 3-[[2-(acetyloxy)ethyl][4-[(4-nitrophenyl)azo]phenyl]amino]propiononitrile
- Cas Number:
- 68391-42-4
- Molecular formula:
- C19H19N5O4
- IUPAC Name:
- 2-[(2-cyanoethyl){4-[(4-nitrophenyl)diazenyl]phenyl}amino]ethyl acetate
- Test material form:
- liquid
- Details on test material:
- Cellitonorange GF2R flüssig
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 10000 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 d
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: short observation period: 7 d
- Mortality:
- No mortality
- Clinical signs:
- other: Slight apathy; faeces, urine and skin systemically stained orange
- Gross pathology:
- Splenomegaly
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (acute, oral) for rats was determined to be >10000 mg/kg bw.
- Executive summary:
The LD50 (acute, oral) for rats was determined to be >10000 mg/kg bw.
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