Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1965-04-09
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report Date:
1965

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Unknown volume of test material was applied to the back and ears of rabbits. Application exposures were 1, 5, 15 minutes and 20h for the back and 20h for ears.
Observations after 24h and 8d.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No information available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
No information available
Duration of treatment / exposure:
Back: 1, 5, 15 minutes and 20h
Ear: 20h
Observation period:
8 days

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
animal:
Remarks:
all
Time point:
7 d
Reversibility:
not reversible
Remarks on result:
probability of severe irritation
Irritant / corrosive response data:
Observations after 24h and 8 days : Skin is bleeding and brown + Necrosis + Desquamation for all time exposures.

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria
Conclusions:
When applied to the skin of rabbits, tributylphosphine results in necrosis and bleeding. The substance is corrosive.
Executive summary:

Although this study lacks details for full reliability, the results show that application of the test item on rabbit skin results in browning of the skin and bleeding after a few minutes or 20h of exposure, respectively. After 8 days, the effects are not reversible. Therefore, tributylphosphine should be regarded as a Corrosive substance.