Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitization predictions.

Vega prediction

Toxtree prediction

WoE prediction

SKIN SENSITIZER

(Not reliable)

NOT SKIN SENSITIZER

(na*)

NOT SKIN SENSITIZER

(na*)

Vega predicted the target Pipamperone as skin sensitizer, however the prediction was assessed as not reliable based on the applicability domain index equal to 0.29. In fact the following issues were encountered: i)only moderately similar compounds have been found in the training set; ii)a prominent number ofatom centered fragments of the target compound have not been found in the compounds of the training set or are rare fragments.

Toxtreepredicted the target Pipamperone asnotskin sensitizer, since it did not identify any skin sensitization reactivity domain alert. A detailed assessment of the reliability of the prediction is not provided by Toxtree.


Migrated from Short description of key information:
Skin sensitization was estimated by employing two predictors: Vega QSAR statistical model and Toxtree decision rule system.

Justification for selection of skin sensitisation endpoint:
In silico prediction

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

In the weight of evidence assessment only reliable predictions are to be taken into account. In the case of the targetPipamperone, Vega prediction resulted to be not reliable, whileToxtree did not identify any skin sensitization reactivity domain alert, leading to a NEGATIVE prediction for skin sensitization. A detailed assessment of the reliability of the weight of evidence prediction was not possible.