Registration Dossier
Registration Dossier
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EC number: 206-376-4 | CAS number: 334-48-5
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
Regarding acute and long-term local effects, local irritation on skin and/or mucous membranes, e. g. eye and respiratory tract as primary effect can be expected for fatty acids with a chain length ≤C12 due to the corrosive/irritation properties of the short- and mid-chain fatty acids C6 – C12, respectively.
Since no adequate dose descriptor for the corrosion/irritation effects are observed, no DNEL is calculated for local effects. However, appropriate risk management measures will be identified.
According to table E.3-1 in the “Guidance on information requirements and chemical safety assessment Part E: Risk Characterisation (ECHA, 2016), decanoic acid is allocated to the low hazard category based on classification as Skin Cat. 2 and Eye Cat. 2 according to Regulation (EC) No 1272/2008.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Regarding acute and long-term local effects, local irritation on skin and/or mucous membranes, e. g. eye and respiratory tract as primary effect can be expected for fatty acids with a chain length ≤C12 due to the corrosive/irritation properties of the short- and mid-chain fatty acids C6 – C12, respectively.
Since no adequate dose descriptor for the corrosion/irritation effects are observed, no DNEL is calculated for local effects.
According to table E.3-1 in the “Guidance on information requirements and chemical safety assessment Part E: Risk Characterisation (ECHA, 2016), octanoic acid is allocated to the moderate hazard category based on classification as Skin Cat. 2 and Eye Cat. 2 according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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