Registration Dossier
Registration Dossier
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EC number: 201-221-7 | CAS number: 79-72-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-aminotoluene-2-sulphonanilide
- EC Number:
- 201-221-7
- EC Name:
- 4-aminotoluene-2-sulphonanilide
- Cas Number:
- 79-72-1
- Molecular formula:
- C13H14N2O2S
- IUPAC Name:
- 5-amino-2-methyl-N-phenylbenzene-1-sulfonamide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 24 h
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- >= 0 - <= 4
- Max. score:
- 105
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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