Registration Dossier
Registration Dossier
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EC number: 928-842-2 | CAS number: 1184648-08-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72h), algae [(R)-2-(4-hydroxyphenoxy)-propanoic acid] 331 mg/L (Memmert, Schreitmüller 1996)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 331 mg/L
- EC10 or NOEC for freshwater algae:
- 46 mg/L
Additional information
The influence of the test substance on the growth of the green algal species Scenedesmus subspicatus CHODAT was investigated in a 72-hour static test according to EU Method C.3 and the OECD Guideline No. 201. The test was performed in compliance with GLP. The test substance had a statistically significant and constant inhibition effect on the growth of Scenedesmus subspicatus after the exposure period of 72 hours first at the nominal concentration of 100 mg test substance/l (= 72-hour LOEC). The 72-hour NOEC was determined to be 46 mg test substance/l, since at this test concentration both the mean biomass and the mean growth rates of the algae were statistically not significantly lower than in the control. The determined 72h EC-values were 122.9 mg/L (biomass) and 331 mg/L (growth rate).
Potassium (R)-2-(4-hydroxyphenoxy)propionate, when dissolved in water becomes equal to the test item (R)-2-(4-hydroxyphenoxy)propanoic acid and toxicity to algae of the potassium salt is therefore equal to the toxicity to algae measured for the acid. It can therefore be concluded by read-across without reasonable doubt that the EC50 (72h) of potassium (R)-2-(4-hydroxyphenoxy)propionate is 331 mg/L and the NOEC is 46 mg/L.
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