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EC number: 701-043-4
CAS number: -
lymph nodes were visibly larger in animals of the test material treated
groups and the positive control group than in vehicle control animals.
This is consistent with the sensitization response attained in the
treated groups and positive control group.
test concentrations, premature deaths or signs of systemic toxicity were
not evident. All control animals and animals treated with 5 or 10% w/v
test material dilution were free from clinical signs or local irritation
during the entire study. At 25 and 50% w/v, all main test animals showed
rigid ears with test item precipitate on them from Day 2 to Day 6,
erythema grade 1 (very slight in degree) and alopecia, the latter
increasing in incidence of affected animals as the study progressed. The
erythema were only transient having disappeared in all animals treated
with 25% w/v by Day 5 and in animals treated with 50% w/v by Day 3 or 4.
Rigid ears, erythema grade 1 and alopecia were also seen in the
pre-screen test [detailed in the above field “Details on study design
was unaffected by treatment with the test material, both in the
pre-screen and in the main test.
local lymph node assay with mice, the stimulation index (SI) threshold
of ≥ 3.0, indicating a positive sensitisation response, was attained in
all treated groups. Therefore, according
to EU classification rules the
test substance was classified as “Category
1” (Warning: May cause an allergic skin reaction) [REGULATION
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