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EC number: 942-466-6 | CAS number: -
No effects after dosing were notes (0.5, 1, 2, 3 and 4 hours after dosing). Considering individual dermal reactions, crust formation was reported for one male animals on day 5, 6 and 7 after dosing. Furthermore, crust formation was reported for five females on day 4, 5, 6 and 7 after dosing.
Table 1. Individual Bodyweights and weekly Bodyweight Changes
For all treated animals and killed on day 14, no abnormalities during macroscopic observation were reported.
Evaluation of Data
Data evaluations included the relationship, if any, between the animal's exposure to the test material and the incidence and severity of all abnormalities
including behavioural and clinical observations, gross lesions, bodyweight changes, mortality and any other toxicological effects.
Using the mortality data obtained, an estimate of the acute dermal median lethal dose (LD50) of the test material was made.
Evaluation of Skin Reaction
Erythema and Eschar Formation Value
0 - No erythema
1 - Very slight erythema (barely perceptible)
2 - Well-defined erythema
3 - Moderate to severe erythema
4 - formation (injuries in depth)
5 - Severe erythema (beet redness) to slight eschar
0 - No oedema
1 - Very slight oedema (barely perceptible)
2 - Slight oedema (edges of area well-defined by definite raising)
3 - Moderate oedema (raised approximately 1 millimetre)
4 - Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure)
Any other skin reactions, if present were also recorded.
A OECD Guideline 402 study was performed to assess the acute dermal toxicity of phosphoric acid, mono- and di-(C8 -C10) ester, compds. with C12-14 amine in the Sprague-Dawley CD strain rat in compliance with GLP. A group of ten animals (five males and five females) was given a single 24-hour, semi-occluded dermal application to intact skin at a dose level of 2000 mg/kg bodyweight. The animals were observed for fourteen days after the day of treatment and were then killed for gross pathological examination. There were no deaths. No signs of systemic toxicity were noted during the study. Signs of skin irritation noted during the study included very slight to well-defined erythema and crust formation. All animals showed an expected gain in bodyweight during the study. No abnormalities were noted at necropsy. The acute dermal median lethal dose (LD50) of the test material in the Sprague- Dawley CD strain rat was found to be greater than 2000 mg/kg bodyweight.
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