Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
other: expert statement
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An extended assessment of the toxicokinetic behaviour of the UVCB substance was performed, taking into account the chemical structure, the available physico-chemical-data and the available toxicity data.

Data source

Reference
Reference Type:
other: Expert Statement
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: TGD, Part I, Annex IV, 2003); ECHA guidance R7c., 2008
Deviations:
no
Principles of method if other than guideline:
An assessment of toxicological behaviour of the UVCB target substance is based on its physico-chemical properties and on the results of available toxicity data data.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Results and discussion

Percutaneous absorption
Parameter:
percentage
Absorption:
50 %
Remarks on result:
other: The absorption following dermal exposure into the stratum corneum is expected to be limited due to the logPow values out of the optimal range favourable for absorption and average MW of 400 g/mol.

Applicant's summary and conclusion

Conclusions:
No significant dermal absorption is expected for the target substance.
Executive summary:

The evaluation of the physico-chemical properties of the target substance and the results of available toxicity studies allow the allocation of the chemical in question into the group of chemicals with a moderate dermal absorption potential. In detail, due to its molecular weight of 400 g/mol and its log Pow values of 0.84, 0.28, and 4.28, respectively for the amine, mono-alkyl phosphate, and di-alkyl phosphate analytes the use of a factor of 50 % for the estimation of dermal uptake would be appropriate.