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EC number: 942-466-6 | CAS number: -
Table 2. Retention times of formamide and reference standards
Retention time [min]
Mean retention time [min]
Formamide (dead time)
Table 3. Capacity factor (k), logk and logKoc for the reference standards
Capacity factor (k)
-2.217 x 10E-2
2.977 x 10E-2
Table 4. Retention time, capacity factors and logKoc for the sample
Retention times [min]
4.716 x 10E-2
4.956 x 10E-2
The determination of the adsorption coefficient was carried out using the High Performance Liquid Chromatography (HPLC) screening method specified in the draft of the OECD Guideline 121 (Lumsden, 1999). The test substance was diluted with methanol. The dead time was determined using formamide and acetanilide, phenol, atrazine, isoproturon, naphthalene, fenthion, alpha endosulfan, pyrazophos, phenanthrene, diclofop-methyl and DDT served as reference standards. The temperature was set at 30 °C and the pH of the mobile phase was measured as 5.9. The measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However the dissociation constants of the test substance are outside the environmental pH range required for this test (it is also not practical to employ such low pH (~3) or high pH (~12) in the test); since adjustment was not environmentally relevant or experimentally practical, measurement was carried out on the ionised form only. A calculated value of adsorption coefficient was derived for each whole salt using a computer-based atom fragment contribution method. The result was logKoc = 4.3 and 6.2. The components of the test substance were also considered and calculated individually. The two acid components gave logKoc values of 1.9 and 3.9, and the amine component gave a logKoc of 2.8. The overall logKoc is in the range < 1.25 - 3.69. The adsorption coefficient (Koc) is therefore in the range < 17.8 - 4.93 x 10E3.
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