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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA).
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
636 000 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Triazines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
117.49 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
466 000 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA).
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
255 000 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Triazines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
117.49 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
205 000 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA).
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
102 000 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Triazines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
117.49 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
90 196.95 mg/L
Remarks on result:
other: Estimated 48-h LC50 for Daphnid (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 48-h LC50 for Daphnia was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Description of key information

Weight of evidence: ECOSAR v1.00a for Triazines, Aliphatic amines and Baseline toxicity. The estimated 48-h LC50 for Daphnia for the three constituents of the test item, were found to be much higher than 100 mg/L.


Supporting study: Read-across from experimental data on P0310. Test method OECD 202. GLP study. The 48-hour NOEC and the 48-hour EC0 to Daphnia magna were determined to be 100 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information

Weight of evidence: The estimated 48-h LC50 for Daphnia for the three constituents of the test item, were found to be much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Supporting study: Based on the read-across approach from experimental data on the analogue P0310 (OECD Guideline 202, GLP study), the 48-hour NOEC and the 48-hour EC0 to Daphnia magna were determined to be 100 mg/L (mean measured concentration of 78 mg/L).