Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 December 2011 to 09 March 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identification FAT 40854/A TE
Description Reddish-brown powder (determined at NOTOX)
Batch TZ 5719 / BOP 02-11
Content 46.2% (4 main constituants)
Test substance storage At room temperature in the dark
Stability under storage conditions Stable
Expiry date 01 April 2016 - Dissociating properties:
- no
- Conclusions:
- No accurate pKa value of the test substance could be determined (OECD 112: titration method).
- Executive summary:
The dissociation constant of FAT 40854/A TE was determined according to OECD 112, EPA OPPTS 830.7370 and GLP.
With both test samples of the preliminary test two equivalence points were observed. With a titration run on a corresponding blank it was demonstrated that one of the equivalence points was related to the background of HCl.
Although an equivalence point of the test substance was found, the value was very close to the equivalence point of HCl and fell in its background. Therefore it was concluded that the main study could not be adequately performed and no accurate pKa value of the test substance could be determined.
Reference
Description of key information
No accurate pKa value of the test substance could be determined.
Key value for chemical safety assessment
Additional information
The dissociation constant of FAT 40854/A TE was determined according to OECD 112, EPA OPPTS 830.7370 and GLP.
With both test samples of the preliminary test two equivalence points were observed. With a titration run on a corresponding blank it was demonstrated that one of the equivalence points was related to the background of HCl.
Although an equivalence point of the test substance was found, the value was very close to the equivalence point of HCl and fell in its background. Therefore it was concluded that the main study could not be adequately performed and no accurate pKa value of the test substance could be determined.
od).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
