Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Basedon the structural similarities between the substance and its analogues, it is concluded that also Ca-DDNSA is not expected to exhibit mutagenic properties.


Justification for selection of genetic toxicity endpoint
Ames tests with the structural analogues DDNSA and DNNSA were both negative

Short description of key information:
DDNSA was tested in a plate incorporation and pre-incubation assay in Salmonella thypimurium strains TA100, TA102, TA97a, TA 98 and TA 1535 in presence and absence of metabolic activation. No mutagenic effects were seen in three experiments. The number of revertant colonies was not increased in comparison with the spontaneous revertants. Therefore the test substance is considered not mutagenic under the test conditions.
An Ames test on the structural analogue DNNSA was negative with and without metabolic activation.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the information two structural analogues, CaDNNSA is not classified for genetic toxicity according to CLP (Regulation EC No 1272/2008) or DSD (Directive 67/548/EEC).