Registration Dossier

Administrative data

Description of key information

DDNSA and DNNSA were applied on the skin of rabbits. For DDNSA, no signs of irritation were observed during the 7 day observation period (PSL, 2001). For DNNSA minor irritation was seen at the 24h and 72 h observations (PSL 1977)
The test substance was shown to be irritant to the eyes when applied in the eyes of 3 rabbits. For DDNSA the effects were reversible after 7 days (PSL, 2001). For DDNSA the effects were not fully reversible after 14 days (PSL 1978)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

CaDDNSA is considered most closely related to DDNSA. As it cannot be excluded that the acidic nature of the analogue(s) has contributed to the effect on the eyes, it is concluded that CaDNNSA is an eye irritant, but is not considered corrosive to the eyes.


Justification for selection of skin irritation / corrosion endpoint:
Two studies similar to a guideline study are avaulable on the analogues DNNSA and DDNSA

Justification for selection of eye irritation endpoint:
DDNSA is irritating to the eyes and DNNSA is severely irritating to the eyes

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the study results, the substance is considered non-irritant to the skin, but irritating to the eyes. According to CLP (Regulation EC No 1272/2008) the substance needs to be classified H319 (category 2: Causes serious eye irritation)