Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics, other
Type of information:
other: expert statement
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Well documented expert statement based on a series of physicochemical, environmental and toxicology studies with WS400123 or a formulation of it, in general performed according to technical guidelines and in compliance with GLP in internationally recognized contract research organizations.
Reason / purpose for cross-reference:
reference to other study

Data source

Reference Type:
study report
Report date:

Materials and methods

Test material

Results and discussion

Applicant's summary and conclusion

Executive summary:

No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400123, a complex mixture of components. Low to moderate absorption and systemic availability of WS400123 or some of its components after oral exposure has been concluded from small, non-adverse changes observed in some blood parameters in the subacute and subchronic toxicity studies in rats. Dermal absorption has been concluded from the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400123.

Exposure of humans to WS400123 by the inhalation route is unlikely, because of its very low vapour pressure (1 x 10-3Pa at 25°C), its decomposition at high temperature without boiling (above ca. 150°C) and because it is a highly viscous liquid.

All available study results gave no indication regarding the distribution, metabolic pathway, or excretion of WS400123.

Bioaccumulation was not investigated, but in view of its Log10Pow< +1, WS400123 is not considered to have a bioaccumulation potential.