Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Article published in established peer-reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
A Toxicological Investigation of Some Acute, Short-Term, and Chronic Effects of Administering Di-2-Ethylhexyl Phthalate (DEHP) and Other Phthalate Esters
Author:
Lawrence, W.H., Malik, M., Turner, J.E., Singh, A.R., and Autian, J.
Year:
1975
Bibliographic source:
Journal of Environmental Research, 9, 1-11.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Details on exposure:
Observation period : 7 days post-doe (end-point - mortality)
Doses:
Not specified
No. of animals per sex per dose:
Groups of 10 males
Statistics:
The LD50 95% confidence interval and slope were calculated from the 7-day mortality data by Cornfield and Mantels' (1950) modification of Karber's method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3.99 other: g/kg bw
Based on:
not specified
95% CL:
>= 3.91 - <= 4.08
Remarks on result:
other: IP LD50 also reported as 3.84 mL/kg bw

Any other information on results incl. tables

Results: IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg

Applicant's summary and conclusion

Conclusions:
Results:
IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg