Registration Dossier
Registration Dossier
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EC number: 606-970-7 | CAS number: 222716-77-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 °C (column temperature)
- Details on study design: HPLC method:
- A limit test was performed as a high logKoc value was anticipated. A solution of the test material (approximately 0.3 g/l in mobile phase) was prepared and chromatographed alongside the reference substance DDT.
EQUIPMENT
- Apparatus:
- Type: Hewlett Packard 1050 Series Liquid Chromatograph
- Type, material and dimension of analytical (guard) column: HyperClone CN (CPS) (25 cm x 4.6 mm internal diameter)
- Detection system: UV set at 210 nm
MOBILE PHASES
- Type: Tetrahydrofuran:water (55:45 v/v)
- Experiments with additives carried out on separate columns: no additives used
- pH: no data
- Solutes for dissolving test and reference substances: HPLC mobile phase
DETERMINATION OF DEAD TIME
- Method: by inert substance which is not retained by the column
REFERENCE SUBSTANCES
- Identity: DDT
- Known logKoc value: 5.6
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 30 µg
- Quantity of reference substances: not reported
- Intervals of calibration: not reported
REPETITIONS
- Number of determinations: not reported
EVALUATION
- Determination of the log Koc value: comparison with the retention time of the reference substance DDT - Key result
- Type:
- log Koc
- Value:
- > 5.6
- Temp.:
- 25 °C
- Details on results (HPLC method):
- The retention times of the main components of the test substance were greater than that of DDT under the test conditions.
- Validity criteria fulfilled:
- not applicable
Reference
Description of key information
Log Koc at 25 °C: > 5.6 (HPLC method; OECD TGD 121, EU Method C.19)
Key value for chemical safety assessment
Additional information
Log Koc at 25°C: > 5.6
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