Registration Dossier

Administrative data

Description of key information

After single oral application the LD 50 in female rats was determined as 1157 mg/kg bw. After single dermal exposure to 2000 mg/kg bw no mortality or other systemic effects were observed. Local irritation occurred at the site of application.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 157 mg/kg bw
Quality of whole database:
reliable without restriction

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
reliable without restriction

Additional information

After single oral application the LD 50 in female rats was determined as 1157 mg/kg bw. After single dermal exposure of male and female Wistar rats to 2000 mg/kg bw no mortality or other systemic effects were observed. Local irritation occurred at the site of application.

Classification: acute oral toxicity cat. 4 due to the observed LD 50 in female rats

No classification for dermal systemic toxicity.

Justification for classification or non-classification

Classification: acute oral toxicity: Cat. 4       H 302

Justification: Observed LD 50 in female rats

No classification for dermal systemic toxicity.