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EC number: 700-158-7 | CAS number: 1092834-40-6
A stimulation index of less than 3 was recorded for the three concentrations of the test material (25%, 10% and 5% w/w in propylene glycol).
Table 1: Disintegrations per Minute, Disintegrations per Minute/Node and Stimulation Index
Concentration (% v/V) in acteone/olive oil 4:1
a= Disintegrations per minute/node obtained by dividing the disintegration per minute value by 8 (total number of lymph nodes)
b= Stimulation Index of 3.0 or greater indicates a positive result
na = not applicable
A study was performed to assess the skin sensitisation potential of the test substance in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear according to OECD Guideline 429 ("Skin Sensitisation: Local Lymph Node Assay"). Following a preliminary screening test in which no clinical signs of toxicity were noted at a concentration of 25% w/w, this concentration was selected as the highest dose investigated in the main test of the Local Lymph Node Assay. Three groups, each of four animals, were treated with 50 μl (25 μl per ear) of the test material as a suspension in propylene glycol at concentrations of 25%, 10% or 5% w/w. A further group of four animals was treated with propylene glycol alone.
The Stimulation Index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group were less than 3 at all tested concentrations. Therefore the test substance SH-1 was considered to be non-sensitising to the skin.
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