Registration Dossier
Registration Dossier
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EC number: 603-525-9 | CAS number: 131860-97-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1992
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Summary report signed by the study director of the original study, and the head of Regulatory genetic Toxicology. No reference is made to GLP. All strains required by guideline OECD 471 tested. The report format does not give all informations required by the guideline: Experimental details and individual data are not provided.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- Not explicitly stated
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- IUPAC Name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- Reference substance name:
- 603-525-9
- EC Number:
- 603-525-9
- Cas Number:
- 131860-97-4
- Molecular formula:
- C15H13ClN2O4
- IUPAC Name:
- 603-525-9
Constituent 1
Constituent 2
Method
- Target gene:
- Not stated, probably hisD3052, hisG46, hisG428 (paQ1), hisC3076
(from choice of bacterial strains)
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- E. coli WP2
- Additional strain / cell type characteristics:
- other: WP2P
- Species / strain / cell type:
- E. coli WP2 uvr A
- Additional strain / cell type characteristics:
- other: WP2PuvrA
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9, not further specified
- Test concentrations with justification for top dose:
- not stated
- Vehicle / solvent:
- not stated
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- Plate incorporation test: on all strains, with and without metabolic activation
Preincubation test: only with strains TA98 and TA100, with metabolic activation only - Evaluation criteria:
- Not specified
- Statistics:
- No data
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'. Remarks: Plate incorporation test: all strains; preincubation test: only strains TA98 and TA100 (+ S9)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
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