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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991 - 1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Summary report signed by the study director of the original GLP study, plus one internal reviewer. The toxicological information contained in the report was derived from studies which fulfill the requirements of GLP. The report format does not give all information required by the guideline: some experimental details and individual data were not provided.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
Not explicitly stated
Deviations:
not specified
GLP compliance:
yes
Remarks:
Confirmed by study director
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
IUPAC Name:
Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
Constituent 2
Chemical structure
Reference substance name:
603-525-9
EC Number:
603-525-9
Cas Number:
131860-97-4
Molecular formula:
C15H13ClN2O4
IUPAC Name:
603-525-9

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
olive oil
Details on dermal exposure:
Test substance applied as a paste
Duration of exposure:
Not explicitly stated, probably 24 hours according to guideline
Doses:
2000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None observed
Clinical signs:
No significant signs of toxicity and no signs of skin irritation were observed

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
For this endpoint the summarised result of one study (CTL, Robinson) is available, which was conducted under GLP. While the full study report is not available, the results are sufficiently detailed and unambiguous as to be suitable for classification and labeling.
It reported no mortalities and no significant signs of toxicity at the limit dose of 2000 mg/kg bw. A dermal LD50 > 2000 mg/kg bw is taken forward for classification and labelling.