Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Read-across was used. Hypothesis for the analogue approach: see files attached under section 13 assessment reports Read Across Justification. Test for source substance to short-term toxicity to aquatic invertebrates was performed according to EU Method C.2 and compliant with GLP.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
GLP compliance:
yes

Test material

Constituent 1
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test solutions

Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: substance was tested without solvent or dispersant.
a) 100 g/l such that after stirring of 68 hours
b) after filtration (concentration maximum 0.6 mg/l in water)

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h

Test conditions

Hardness:
250 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 0.6 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 0.6 mg/L
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 0.6 mg/L
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 0.6 mg/L
Details on results:
%Concentration loss over test: 20...30

Applicant's summary and conclusion

Conclusions:
The test substance (source substance) bis(hydrogenated tallow C16-C18-alkyl)hydroxylamine is a structurally very similar substance to target substance hydroxylamines, di-C16-18 (even numbered) alkyl. It can be reasonably assumed that target substance has the same properties. However, care should be exercised in the interpretation of the data of source substance, since the source substance was tested at levels above its water solubility of target substance. For the target substance, no toxic effects shall occur within the range of solubility (0.13 mg/L) .