Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Read-across was used. Hypothesis for the analogue approach: see files attached under section 13 assessment reports Read Across Justification. Test for source substance to partition coefficient was performed compliant with GLP.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: calculation method was used .
GLP compliance:
yes
Type of method:
other: calculation method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
ca. 14.5
Temp.:
20 °C
pH:
7
Remarks on result:
other: The calculated values are in a range of 5.5 to 25. The Log Pow of the main component is 14.5.

Applicant's summary and conclusion

Conclusions:
The partition coefficient of test substance was calculated in a range of 5.5 to 25. Log Pow of main constituent was calculated to be ca. 14.5 at 20°C. The tested substance (source substance) bis(hydrogenated tallow C16-C18-alkyl)hydroxylamine is a structurally very similar substance to target substance hydroxylamines, di-C16-18 (even numbered) alkyl. It can be reasonably assumed that target substance has the similar partition coefficient range.