Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
< 0 g/L
Temp.:
20 °C
pH:
>= 6.19 - <= 6.43

The preliminary test gave a result of less than 6.16 x 10-7 g/L which, according to the relevant test guidelines, means that the definitive test should be performed using the column elution method. However, the flask method was used instead for the following reasons. There were practical concerns when considering the column elution method, namely that the analysis procedure required large volumes of sample for extraction. As the column elution method requires a reservoir from which multiple samples are taken, the total volume of this reservoir would need to be so large as to make testing impractical using this method; this being compared to the flask method where there is no requirement for many samples to be taken from each system. Finally, as the test item is an ester, there was also some concern over the stability of the test item in aqueous solution over the longer periods required for the column elution compared to the flask method. For these reasons it was considered acceptable to use the flask method for the definitive testing rather than the column elution method. On completion of the equilibration period, the samples were clear and colorless with excess test item present at the bottom and on the surface of the water in the test vessels. The solutions were decanted, avoiding excess test item and filtered and the supernatant was taken for analysis. The supernatant was visually observed to be clear/colorless and free from un-dissolved test item. As no test item was detected in the samples the limit value calculated was used as the upper limit of water solubility.

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of the test material was assessed according to OECD Guideline 105 and determined to be less than 0.000000616 g/L at 20 ± 0.5 ºC.

Description of key information

The water solubility of the test material was assessed according to OECD Guideline 105 and determined to be less than 0.000000616 g/L at 20 ± 0.5 ºC.

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was assessed according to OECD Guideline 105 and determined to be less than 0.000000616 g/l of solution at 20.0 ± 0.5°C.

As no test item was detected in the samples the limit value calculated was used as the upper limit of water solubility.