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EC number: - | CAS number: -
Intact skin reactions
Abraded skin reactions
The skin irritation potential was tested in New Zealand White rabbits. The procedure used is described in the Proposed Guidelines of the United States Environmental Agency (EPA) § 163.81-5 "Primary dermal irritation study", Federal Register, Vol. 43, No. 163, August 22, 1978.
Under the conditions of the present experiment the test compound was found to cause a slight irritation when applied to intact and abraded rabbit skin. One animal died after 6 days.
The scoring system criteria used to record the hardness of the skin reactions followed in the current test are the same as those reported into the OECD guideline, therefore it is possible to re-evaluate the results according to the CLP Regulation (1272/2008), because the raw tables are included into the study report. Only the intact skin reactions were considered.
Mean values from gradings at 24, 48 and 72 hours after patch removal were lower than 2.3 in all animals for both erythema/eschar and oedema reactions (in both intact and abraded skin).
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