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Description of key information

Two groups, each of three female HanRcc:WIST (SPF) rats, were treated with FAT 40842/A TE by oral gavage administration at a dosage of 2000 mg/kg body weight. The test item was diluted in vehicle (PEG 300) at a concentration of 0.2 g/mL and administered at a dosing volume of 10 mL/kg.
The median lethal dose of FAT 40842/A TE after single oral administration to female rats, observed over a period of 14 days is: LD50 (female rat): greater than 2000 mg/kg body weight

Key value for chemical safety assessment

Additional information

All animals survived until the end of the study period.

All animals showed green stained faeces at the 5-hour reading up to test day 2 or from test day 2 to 4. Otherwise, no clinical signs were noted.

The body weight of the animals was within the range commonly recorded for this strain and age.

No macroscopic findings were recorded at necropsy.

Justification for classification or non-classification

The median lethal dose of FAT 40842/A TE after single oral administration to female rats, observed over a period of 14 days is: LD50 (female rat): greater than 2000 mg/kg body weight

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