Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 October 2015 to 10 October 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Identification: FAT 40138/G TE
Lot: 52-54
Appearance: Yellow powder
Key result
Water solubility:
89 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: The preliminary visual experiments showed that the water solubility of the test item is between 50 g/l and 100 g/l. Final result obtained as an average of 3 experiments = 89 g/l

The water solubility of the test item at a temperature of 20 °C based on the average of three experiments was determined to be 89 g/L.

The recovery of 100.8 % indicated a sufficient accuracy of the analytical method.

Table: Solubility of the test item –experiments A to D

Experiment

A

B

C

D (blank)

Amount of test item (mg)

2500

2500

2500

--

Stirring time at 30°C (h)

24

48

72

72

Measured concentration (µg/ml)

5.4

5.5

5.7

--

Dilution

0.05ml/10ml/ 0.125 ml/10ml

0.05ml/10ml/ 0.125 ml/10ml

0.05ml/10ml/ 0.125 ml/10ml

--

Solubility (g/l)

86.4

88.7

91.6

--

 

Table: Concentrations of the standards for recheck:

Standard

Measured concentration (µg/ml)

% Recovery

Solution C + 5.7 µg

11.5

100.8

 

The recovery of 100.8 % indicates a sufficient accuracy of the analytical method.

Conclusions:
The water solubility of FAT 40138/G at a temperature of 20 °C was determined to be 89 g/l.
Executive summary:

The water solubility of the test substance was investigated in a study conducted according to OECD Guideline 105 and EU Method A.6. Flask method was used for this purpose, while VIS-spectroscopy was used for the detection of the concentration of the test substance. Based on the findings of the study, the water solubility of the test substance at a temperature of 20 °C was determined to be 89 g/l.

Description of key information

The water solubility of the test substance was investigated in a study conducted according to OECD Guideline 105 and EU Method A.6. Flask method was used for this purpose, while VIS-spectroscopy was used for the detection of the concentration of the test substance. Based on the findings of the study, the water solubility of FAT 40138/G at a temperature of 20 °C was determined to be 89 g/l.

Key value for chemical safety assessment

Water solubility:
89 g/L
at the temperature of:
20 °C

Additional information