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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
explosiveness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.14 (Explosive properties)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Loperamide
EC Number:
258-416-5
EC Name:
Loperamide
Cas Number:
53179-11-6
Molecular formula:
C29H33ClN2O2
IUPAC Name:
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Details on test material:
Test item identification : 4-(4-clorofenil)-4-idrossi-N,N-dimetil-a,a-difenil-1--piperidinbutanamide
Purity : 99.7 % w/w
Expiry date : June 01, 2015

Results and discussion

Small-scale preliminary testsopen allclose all
Parameter:
other: More sensitive to shock than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Parameter:
other: More sensitive to friction than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Parameter:
other: Explosive under influence of flame
Remarks:
migrated information
Remarks on result:
negative (not further specified)

Any other information on results incl. tables

Thermal sensitivity (effect of flame)

None of the six tests (three of them with the 6 mm orifice plate and the remaining with the 2 mm orifice plate) gave rise to explosion or breaking of any tube.

In the three tests with the 6 mm orifice plate the following phenomena were observed:

a flame generation began in the test chamber after about 39 seconds with a formation of light sparks; the intense phase started after about 70 seconds with a flame increasing and a formation of black smoke and ended after about 83 seconds.

After about 200 seconds all phenomena ended. In the three tests with the 2 mm orifice plate similar phenomena to 6 mm orifice plate were observed. The test result is considered negative.

Mechanical sensitivity (effect of shock)

No explosion was obtained during the series of six tests at 40 J performed on the test item

(bursting into flame and/or a report is equivalent to explosion). The test result is considered negative.

Mechanical sensitivity (effect of friction)

No explosion was obtained during the series of six tests performed with 360 N loading on the

test item (crackling and/or a report or busting into flame are equivalent to explosion).

The test result is considered negative.

Applicant's summary and conclusion

Interpretation of results:
non explosive
Remarks:
Migrated information
Conclusions:
From the experimental data obtained according to A.14 method in Council Regulation (EC)
No 440/2008 of 30 May 2008, it can be concluded that the 4-(4-chlorophenyl)-4-hydroxy-N,Ndimethyl-
a,a-diphenyl sample does not present explosive properties.