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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
not specified
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Solubility in organic solvents
Author:
Lide D.R.
Year:
2008
Bibliographic source:
Lide D.R., CRC Handbook of Chemistry and Physics 88th Edition 2007-2008, CRC Press, Taylor & Francis, p. 3-320 (2008); Lide D.R., CRC Handbook of Chemistry and Physics 88th Edition 2007-2008, CRC Press, Taylor & Francis, p. 3-320 (2008)

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
method not known
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ergosterol
EC Number:
200-352-7
EC Name:
Ergosterol
Cas Number:
57-87-4
Molecular formula:
C28H44O
IUPAC Name:
ergosta-5,7,22-trien-3-ol
Test material form:
solid: particulate/powder

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Key result
Medium:
other: chloroform
Solubility:
20 g/kg solvent
Temp.:
18 °C
Key result
Medium:
diethyl ether
Solubility:
20 g/kg solvent
Temp.:
20 °C
Key result
Medium:
acetone
Solubility:
5 g/kg solvent
Temp.:
22 °C
Key result
Medium:
benzene
Solubility:
10.638 g/kg solvent
Temp.:
16 °C

Any other information on results incl. tables

Value:1 g / 50 g chloroform (18°C)

Reference:Tanret M.C., Sur l’ergostérine et la fongistérine, Annales de Chimie, Serie 8,15,

p. 313-330 (1908);

Reference:Tanret, Bulletin de la Société Chimique de France, Serie 4,31, p. 444-446 (1922);

 

***

Value:1 g / 31 ml chloroform

Reference:The Merck Index – An Encyclopedia of Chemicals, Drugs and Biologicals, O’Neil

M.J. (editor), Merck & Co., p. 626 (2006);

 

***

Value:1 g / 50 g diethyl ether (20°C)

1 g / 28 g diethyl ether (boiling)

Reference:Tanret M.C., Sur l’ergostérine et la fongistérine, Annales de Chimie, Serie 8,15,

p. 313-330 (1908);

Reference:Tanret, Bulletin de la Société Chimique de France, Serie 4,31, p. 444-446 (1922);

 

***

Value:14.286 g/l diethyl ether (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

***

Value:1 g / 200 g acetone (22°C)

1 g / 32 g acetone (boiling)

Reference:Tanret M.C., Sur l’ergostérine et la fongistérine, Annales de Chimie, Serie 8,15,

p. 313-330 (1908);

Reference:Tanret, Bulletin de la Société Chimique de France, Serie 4,31, p. 444-446 (1922);

 

***

Value:37.037 g/l acetone (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:153.846 g/l ethyl acetate (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:28.571 g/l methyl acetate (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

***

Value:100 g/l 2-propanol (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:1 g / 94 g benzene (16°C)

Reference:Tanret M.C., Sur l’ergostérine et la fongistérine, Annales de Chimie, Serie 8,15,

p. 313-330 (1908);

Reference:Tanret, Bulletin de la Société Chimique de France, Serie 4,31, p. 444-446 (1922);

 

***

Value:217.391 g/l benzene (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:41.667 g/l hexane (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:3.571 g/l methanol (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:20 g/l ethanol (boiling)

Reference:Honeywell E.M., Bills Ch.E., Cerevisterol, a sterol accompanying ergosterol in

yeast, Journal of Biological Chemistry,99(1), p. 71-78 (1932);

 

***

Value:1 g / 526 g ethanol/water

1 g / 36 g ethanol/water (boiling)

Reference:Tanret M.C., Sur l’ergostérine et la fongistérine, Annales de Chimie, Serie 8,15,

p. 313-330 (1908);

Reference:Tanret, Bulletin de la Société Chimique de France, Serie 4,31, p. 444-446 (1922);

 

***

Value:slightly soluble in ethanol, ethyl ether, petroleum ether; soluble in benzene,

chloroform

Reference:Lide D.R., CRC Handbook of Chemistry and Physics 88thEdition 2007-2008, CRC

Press, Taylor & Francis, p. 3-320 (2008);

Applicant's summary and conclusion

Conclusions:
Slightly soluble in ethanol, ethyl ether, petroleum ether; soluble in benzene,chloroform.
Executive summary:

1 g / 50 g chloroform (18°C)

1 g / 31 ml chloroform

1 g / 50 g diethyl ether (20°C)

1 g / 28 g diethyl ether (boiling)

14.286 g/l diethyl ether (boiling)

1 g / 200 g acetone (22°C)

1 g / 32 g acetone (boiling)

37.037 g/l acetone (boiling)

153.846 g/l ethyl acetate (boiling)

28.571 g/l methyl acetate (boiling)

100 g/l 2-propanol (boiling)

1 g / 94 g benzene (16°C)

217.391 g/l benzene (boiling)

41.667 g/l hexane (boiling)

3.571 g/l methanol (boiling)

20 g/l ethanol (boiling)

1 g / 526 g ethanol/water

1 g / 36 g ethanol/water (boiling)