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EC number: 208-792-1
CAS number: 541-73-1
m-dichlorobenzene was administered once orally by gavage in a single
dose of 1000 mg/kg bodyweight to male and female Chinese hamsters. This
dose had been shown in a preliminary study tobe the maximum tolerated
A positive control group, induced exactly 24 hours later to run parallel
with the negative control and the dose group, received Endoxan in an
oral dose of 50 mg/kg bodyweight.
Animals from each group were killed 12, 24 and 48 hours after treatment
by carbon dioxide asphyxiation. 5 males and 5 females from each group
were killed at each of these times.
The bone marrow obtained from femora of the animals was prepared, placed
on microskopic slides and stained, after which 50 metaphases per animal
were evaluated. The completeness in the number of chromosomes and the
various chromatic and chromosomal aberrations were assessed.
Under the conditions of the present study, m-dichlorobenzene caused no
significant increase in the aberration rate in the bone marrow cells of
the treated animals as compared with the control group.
Endoxan however produced a marked i ncrease in the aberration rate in
the test animals.
The results indicate that, under the conditions of the present study,
m-dichlorobenzene is not mutagenic in the in vivo chromosome aberration
test in bone marrow cells of the Chinese hamster.
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