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EC number: 208-792-1 | CAS number: 541-73-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method not stated
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: logPow
- Type:
- log Pow
- Partition coefficient:
- 3.53
- Remarks on result:
- other: Temp and pH not reported
- Conclusions:
- The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at 3.53.
- Executive summary:
The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at 3.53.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method not stated
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: logPow
- Type:
- log Pow
- Partition coefficient:
- 3.48
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not available
- Conclusions:
- The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at 3.48 at 25 °C.
- Executive summary:
The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at 3.48 at 25 °C.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.53
- Temp.:
- 22 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- The partition coefficient of 1,3 dichlorobenzene was determined at log Pow = 3.53 at 22 °C, based on the shake-flask method.
- Executive summary:
The partition coefficient of 1,3 dichlorobenzene was determined at log Pow = 3.53 at 22 °C, based on the shake-flask method.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- number of duplicate runs not given (potentially 2 instead of 3), log POW values fall within a range of ± 0.6 units (instead of 0.3 units), no data given about impurities, amount of test substance, POW values and their mean for each set of test conditions,
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: LSC= liquid scintillation counting
- Type:
- Pow
- Partition coefficient:
- 2 750
- Temp.:
- 23 °C
- Remarks on result:
- other: pH not specified
- Type:
- log Pow
- Partition coefficient:
- 3.44
- Temp.:
- 23 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at 3.44 at 23 °C.
- Executive summary:
The octanol/water partition coefficient (Pow) of 1,3 -dichlorobenzene is 2750 at 23 °C and the log Pow was 3.44 at 23 °C.
Test similar to OECD 107 (shake-flask method).
Deviations are: number of duplicate runs not given (potentially 2 instead of 3), Log Pow values fall within a range of ± 0.6 units (instead of 0.3 units); no data about impurities and amount of test substance, individual Pow values and means for each set of test conditions not reported.
Referenceopen allclose all
Temperature and pH not reported.
pH not reported.
pH not reported.
Description of key information
The partition coefficient (log Pow) of 1,3-dichlorobenzene was determined at:
- Log Pow 3.44 at 23°C (Banerjee 1980)
- Log Pow 3.53 at 22 °C (Koennemann 1979)
- Log Pow 3.53 (IPCS-INCHEM 2014)
- Log Pow 3.48 at 25 °C ( Lide, 2014)
A WoE was performed to assess the partition coefficent for 1, 3-dichlorobenzene based on available studies. The higher result was chosen as key value.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.495
- at the temperature of:
- 23.3 °C
Additional information
pH values not reported
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