Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007
Reliability:
1 (reliable without restriction)
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical monitoring:
yes
Buffers:
pH 4, 7 and 9
Duration of testopen allclose all
Duration:
144 h
pH:
3.95
Temp.:
50 °C
Initial conc. measured:
ca. 10 mg/L
Duration:
144 h
pH:
6.92
Temp.:
50 °C
Initial conc. measured:
ca. 10 mg/L
Duration:
144 h
pH:
8.92
Temp.:
50 °C
Initial conc. measured:
ca. 10 mg/L
Number of replicates:
2
Negative controls:
yes
Remarks:
Buffer solutions (ph value 4, 7, and 9)

Results and discussion

Preliminary study:
the test item was found to be stable in the preliminary test at pH 4, 7 and 9 at 50°C.
Transformation products:
no
Details on hydrolysis and appearance of transformation product(s):
according to the corresponding guideline the main test is not necessary. A half life time of > 1 year can be concluded

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Based on the preliminary test it can be calculated that substance has a half life time > 1 year at pH 4, 7 and 9.