Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 606-790-9 | CAS number: 215247-95-3
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 49 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 36
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 763 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The corrected inhalatory NOAEC is obtained by multiplying (allometric scaling) the NOAEL with 1/0.38 m³/kg/day * 6.7 m³ / 10 m³ as 1763 mg/m³ .
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 6
- Justification:
- chronic to subacute extrabolation according to guidance
- AF for interspecies differences (allometric scaling):
- 3
- Justification:
- based on ECETOC (2010) (Technical Report ‘Guidance on Assessment Factors to Derive DNELs’, European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Brussels, Belgium, 2010)
- AF for other interspecies differences:
- 1
- Justification:
- based on ECETOC (2010) (Technical Report ‘Guidance on Assessment Factors to Derive DNELs’, European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Brussels, Belgium, 2010)
- AF for intraspecies differences:
- 1
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 2
- Justification:
- see explanation below
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 24
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
see explanation below
- AF for dose response relationship:
- 1
- Justification:
- see explanation below
- AF for differences in duration of exposure:
- 2
- Justification:
- see explanation below
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- see explanation below
- AF for other interspecies differences:
- 1
- Justification:
- see explanation below1000
- AF for intraspecies differences:
- 3
- Justification:
- see explanation below
- AF for the quality of the whole database:
- 1
- Justification:
- see explanation below
- AF for remaining uncertainties:
- 1
- Justification:
- see explanation below
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: based on ECETOC (2010) (Technical Report ‘Guidance on Assessment Factors to Derive DNELs’, European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Brussels, Belgium, 2010)
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- See explanation below
- AF for differences in duration of exposure:
- 2
- Justification:
- See explanation below
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- See explanation below
- AF for other interspecies differences:
- 1
- Justification:
- See explanation below
- AF for intraspecies differences:
- 5
- Justification:
- See explanation below
- AF for the quality of the whole database:
- 1
- Justification:
- See explanation below
- AF for remaining uncertainties:
- 1
- Justification:
- See explanation below
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: See explanation below
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- See explanation below
- AF for differences in duration of exposure:
- 2
- Justification:
- See explanation below
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- See explanation below
- AF for other interspecies differences:
- 1
- Justification:
- See explanation below
- AF for intraspecies differences:
- 5
- Justification:
- See explanation below
- AF for the quality of the whole database:
- 1
- Justification:
- See explanation below
- AF for remaining uncertainties:
- 1
- Justification:
- See explanation below
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
