Papaverine

GHS

General Information

Name:

CLP

Implementation:

EU

Remarks:

The substance is listed in Annex VI of CLP as Acute Tox 4.

This substance is currently listed on the substances list published by ECHA of those whose met REACH Annex III criteria.

The Annex III inventory is an advisory list, there are not detailed information about the used model and the predictions do not follow OECD principles.

Therefore, the following data can only be used as screening information, but they are not to be considered relevant for the classification and labelling :

# Suspected hazardous to the aquatic environment:

Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is Toxic-3 (between 10 and 100 mg/l) (moderate reliability);

Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 11.25 mg/L (moderate reliability); has a 96h LC50 to fish of 8.5 mg/L; has a 48h EC50 to Daphnia of 5.64 mg/L; has a 96h EC50 to green algae of 8.01 mg/L

# Suspected mutagen: The Toolbox profiler Protein binding alerts for Chromosomal aberration by OASIS v1.1 gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (good reliability)

# Suspected persistent in the environment: The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable

Related composition

Related composition:

Boundary composition

Legal Entity Composition

Classification

Physical hazards

Explosives

Reason for no classification:

data lacking

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data lacking

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data lacking

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data lacking

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data lacking

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 4

Hazard statement:

H302: Harmful if swallowed.

Acute toxicity - dermal

Reason for no classification:

data lacking

Acute toxicity - inhalation

Reason for no classification:

data lacking

Skin corrosion / irritation

Reason for no classification:

data lacking

Serious eye damage / eye irritation

Reason for no classification:

data lacking

Respiratory sensitisation

Reason for no classification:

data lacking

Skin sensitisation

Reason for no classification:

data lacking

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data lacking

Carcinogenicity

Reason for no classification:

data lacking

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data lacking

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data lacking

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Reason for no classification:

data lacking

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data lacking

Hazardous to the ozone layer

Reason for no classification:

data lacking

Labelling

Signal word:

Warning

Hazard pictogram

GHS07: exclamation mark

Hazard statements

H302: Harmful if swallowed.

Precautionary statements

P260: Do not breathe dust/fume/gas/mist/vapours/spray.

P302+P352: IF ON SKIN: Wash with plenty of water/…

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/…