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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Journal of the American College of Toxicity

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Probably no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-morpholinoethanol
Constituent 2
Reference substance name:
O(CCN(C1)CCO)C1
IUPAC Name:
O(CCN(C1)CCO)C1

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Details on study design:
Protocol: Test article (0.1 ml) was administrated directly to one eye of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Ocular scoring of corneal, irridial, and conjuctival lesions with calculations of an ocular irritation score according to Draize et al. (1944). Study duration was 7 days.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
5.2
Reversibility:
fully reversible within: 7 days
Irritant / corrosive response data:
Draize ocular irritation score = 5.2 of 110 @ 24 hours post treatment ; considered minimally irritating. Slight ocular irritation was observed through 72 hours. All scores returned to normal by day 7.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The intermediate substance is not classified with regards to Eye irritation according to CLP Criteria

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