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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Journal of the American College of Toxicity

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Probably no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-morpholinoethanol
Constituent 2
Reference substance name:
O(CCN(C1)CCO)C1
IUPAC Name:
O(CCN(C1)CCO)C1

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Details on study design:
Protocol: Test article (0.5 ml) was applied to shaved skin sites (intact and abraded, occluded) of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Dermal scoring of erythema and edema on both skin sites at 24 and 72 hours, and calculation of the primary irritation index, was performed according to Draize (1959). Study duration was 4 days.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
72 h
Score:
0.66
Reversibility:
fully reversible within: 4 days
Irritant / corrosive response data:
Draize Primary Irritation Index = 0.66 of 8.0; considered to be minimally irritating. Slight to well-defined erythema was observed only at the 24 hour observations; very slight edema was observed at the 72 hour observations. All scores returned to normal by the 4 day observations.

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Conclusions:
The intermediate substance is not classified with regards to Skin irritation according to CLP Criteria

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