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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Journal of the American College of Toxicity

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Probably no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-morpholinoethanol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
other: non-occluding dressings
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Protocol: Four exposure groups (6.3, 8.0, 10.0 and 16.0 g/kg, determined by a prescreen) of 4 New Zealand White rabbits (5/sex), weighing 2 to 3 kg, received test article on shaved, intact skin of their backs (about 10 % of total body area), for 24 hours using non-occluding dressings. Study duration was 14 days.
Duration of exposure:
14 days
Doses:
6.3, 8.0, 10.0 and 16.0 g/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: no data

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality pattern: 1/10 @ 6.3 g/kg ; 0/10 @ 8.0, 10.0, 16.0 g/kg
Other findings:
Necropsy findings (study death): determined that death was not compound related. terminal necropsy: no visible lesions were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The intermediate substance is not classified with regards to Dermal Acute Toxicity

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