Zinc bis(dinonylnaphthalenesulphonate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1978

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: limited report, non-GLP, not all parameters investigated, exposure duration only 1 hour. The information in the report is limited to the information in the summary.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: FHSLA, CFR, Title 21, para. 191.10

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Zinc bis(dinonylnaphthalenesulphonate)

EC Number:

248-778-2

EC Name:

Zinc bis(dinonylnaphthalenesulphonate)

Cas Number:

28016-00-4

Molecular formula:

Zn[C28H43O3S]2

IUPAC Name:

Zinc bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate))

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: not indicated
- Weight at study initiation: males: 235-291 g; females 225 -292 g
- Fasting period before study: NA
- Housing: group
- Diet: ad libitum
- Water: ad libitum:
- Acclimation period: not indicated

ENVIRONMENTAL CONDITIONS: no information available

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION: no data available
The substance was vapourized according to the report. However in view of the low vapour pressure of both the test substance and the diluent oil (very viscous formulation), it seems more likely that an aerosol was generated

TEST ATMOSPHERE (if not tabulated): no data

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 1 h

Concentrations:

7.6 mg/L (calculation based on concentration)

No. of animals per sex per dose:

5 males + 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily for clinical signs and mortality; frequency of weighing not indicated (only starting weight reported)
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

NA

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 7.6 mg/L air (nominal)

Based on:

act. ingr.

Exp. duration:

1 h

Effect levels 2

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 19 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Mortality:

none

Clinical signs:

other: none reported

Body weight:

no data

Gross pathology:

not performed

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LC50 for the test substance is > 7.6 mg/L

Executive summary:

Rats (5/sex) were exposed to the test substance at 7.6 mg/L by inhalation during 1 hour. No mortality or clinical signs were observed during the 14 day observation period. It is therefore concluded that the LC50 is >7.6 mg/L