Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Qualifier:
according to guideline
Guideline:
other: Directive 92/69 EEC B.5
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(3-Chloro-4-hydroxyphenyl)ethanone
Cas Number:
2892-29-7
Molecular formula:
C8 H7 Cl O2
IUPAC Name:
1-(3-Chloro-4-hydroxyphenyl)ethanone
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals / tissue source

Species:
rabbit
Strain:
Wistar

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1g
Observation period (in vivo):
72 hours - 10 days
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
animals #1 #2 #3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Remarks:
animals #1, #2, #3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
animals #1, #2, #3
Time point:
other: 24, 48, 72 hours
Score:
>= 1 - <= 1.67
Max. score:
3
Reversibility:
fully reversible within: 10days
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
animals #1, #2, #3
Time point:
other: 24, 48, 72 hours
Score:
>= 0.33 - <= 1
Max. score:
4
Reversibility:
fully reversible within: 10 days
Irritation parameter:
other: discharge
Basis:
mean
Remarks:
animals #1, #2, #3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
3
Irritant / corrosive response data:
changes fully reversible within 8 days (animal 1), 10 days (animal 2), 7 days (animal 3).

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
the substance produced irritating effects, which were reversible, but no corrosion.