Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
other: OPPTS 870.1000 "Acute toxicity testing background"
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(3-Chloro-4-hydroxyphenyl)ethanone
Cas Number:
2892-29-7
Molecular formula:
C8 H7 Cl O2
IUPAC Name:
1-(3-Chloro-4-hydroxyphenyl)ethanone
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
cotton seed oil
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 2 000 - <= 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No treatment related effects were observed in any animals of steps 1 and 2
Clinical signs:
No treatment related effects were observed in any animals of steps 1 and 2

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
the product showed no oral toxic characteristicsLD50 cut off: >2000 to 5000 mg/kg bw