Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Reaction mass of SIBX are related compound to SEX

Data source

Reference
Reference Type:
publication
Title:
Metabolism of xanthates in man and guinea pig
Author:
Merlevede E and Peters J
Year:
1965
Bibliographic source:
Archives of the Belgian Medical Society, 23(8): 513-551

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium O-ethyl dithiocarbonate
EC Number:
205-440-9
EC Name:
Sodium O-ethyl dithiocarbonate
Cas Number:
140-90-9
Molecular formula:
C3H6OS2.Na
IUPAC Name:
sodium O-ethyl dithiocarbonate
Test material form:
solid: compact
Details on test material:
- Name of test material (as cited in study report):sodium ethyl xanthate

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Doses:
70-200 mg/kg of potassium ethyl xanthate
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: elimination of CS2
Effect level:
> 70 - < 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximum elimination between 1 - 2 h in most animals.
Sex:
not specified
Dose descriptor:
other: elimination of CS2
Effect level:
> 50 - < 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h

Any other information on results incl. tables

Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximumelimination between 1 - 2 h in most animals. The rate of elimination was doserelated,however the total percentage recovered was independent of dose. A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, withmaximum elimination at 1 h (total recovery of CS2 was not reported).

Applicant's summary and conclusion

Conclusions:
Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximum elimination between 1 - 2 h in most animals. The rate of elimination was dose related, however the total percentage recovered was independent of dose. A more rapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h (total recovery of CS2 was not reported).