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EC number: 222-164-4 | CAS number: 3375-31-3
At 5110 mg/kg bw all animals had diarrhoea and exhibited slight to severe hypokinesia. Stilted gait, diarrhoea, sunken sides, piloerection, vocalization on handling and strenuous respiration were noted in some animals. One male and two females also had a brown nasal discharge. Symptoms were recorded 30 min after dosing and were reported to last for up to 9 days. One female exhibited clonic convulsions, decreased muscle tone, loss of righting reflex and decreased body surface temperature before death on day 4 after dosing.
At 2370 mg/kg bw all animals had diarrhoea and slight to moderate hypokinesia, 4 had sunken sides and individual animals exhibited a stilted gait and piloerection.
No gross abnormalities were evident at necropsy in the rats that survived the observation period. The deceased female had pale spots in the heart and kidneys and haemorrhages in the stomach.
Histological examination revealed single focal proximal tubular cell hyperplasia with some eosophilic material in the tubules of some animals dosed at 5110 mg/kg bw. Minimal focal mononuclear cell infiltration was detected in the heart and kidneys of some of these rats. The deceased rat exhibited acute single cell necroses in the heart, massive diffuse necroses of the proximal and distal renal tubular cells with deposition of eosinophilic material and massive storage of slightly basophilic material in proximal renal tubules.
At 2370 mg/kg bw one female showed minimal mononuclear cell infiltration and minimal focal interstitial nephritis. No abnormalities were detected in the heart in animals given this dose.
The acute oral LD50 value was found to exceed 5110 mg/kg bw (limit test).
Based on the results of this study, palladium (II) acetate should not be classified for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
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