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Ecotoxicological information

Toxicity to birds

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to birds
Data waiving:
other justification
Justification for data waiving:
other:

Description of key information

According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE , study for effects on terrestrial organisms and plants  need not be conducted if:
- These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely.
Bioaccumulation is considered to be low for Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol which is rapidly metabolised in higher organisms.

The estimated Log BCF of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is 1.86 (BCF = 71.8 L/kg wet-wt). This substance has a limited potential to bioaccumulate (based on log Kow used by BCF estimates: 3.32, and predicted bioconcentration factors, log BCF = 1.86 (EPIWIN/BCF Program).

Two evidences result in the conclusion that Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-olis not expected to be B/vB:

-The chemical belongs to the thiocarbamate group. In general, thiocarbamates are absorbed via the skin, mucous membranes, respiratory and gastrointestinal tracts, with rapid elimination via expired air and urine.
-Thiocarbamates are also rapidly metabolised, producing either mercapturic acid compounds or compounds that enter the carbon metabolic pool

Therefore, Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is not considered to be bioaccumulative and secondary poisoning is not considered relevant.

Key value for chemical safety assessment

Additional information

According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE , study for effects on terrestrial organisms and plants need not be conducted if:

- These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely.

Bioaccumulation is considered to be low for Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol which is rapidly metabolised in higher organisms.

The estimated Log BCF of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is 1.86 (BCF = 71.8 L/kg wet-wt). This substance has a limited potential to bioaccumulate (based on log Kow used by BCF estimates: 3.32, and predicted bioconcentration factors, log BCF = 1.86 (EPIWIN/BCF Program).

Two evidences result in the conclusion that Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-olis not expected to be B/vB:

-The chemical belongs to the thiocarbamate group. In general, thiocarbamates are absorbed via the skin, mucous membranes, respiratory and gastrointestinal tracts, with rapid elimination via expired air and urine.

-Thiocarbamates are also rapidly metabolised, producing either mercapturic acid compounds or compounds that enter the carbon metabolic pool

Therefore, Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is not considered to be bioaccumulative and secondary poisoning is not considered relevant.