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Toxicity to terrestrial plants

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Endpoint:
toxicity to terrestrial plants: long-term
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable. QSAR model
Analytical monitoring:
not required
Vehicle:
no
Species:
other: Terrestrial plants,QSAR model
Plant group:
other: QSAR model
Details on test organisms:
no further information
Test type:
other: QSAR
Study type:
other: QSAR
Substrate type:
other: QSAR
Limit test:
no
Total exposure duration:
30 d
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Moisture:
not applicable. QSAR model
Details on test conditions:
SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate)
Reference substance (positive control):
no
Species:
other: Terrestrial plants,QSAR model
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
4.529 mg/kg soil dw
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Species:
other: Terrestrial plants,QSAR model
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
2.156 mg/kg soil dw
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: cited as a ChV value, 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Details on results:
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Overview of QSARs estimations ontoxicity of O-isopropyl ethylthiocarbamate (IPETC ) to terrestrial plants 

Method

 

Results

Remarks

Reference

QSAR

estimate

 Terrestrial plants ,96-hrEC50 = 4.529 mg/L (ppm)

 Terrestrial plants, 30-day, ChV (chronic value) =2.156 mg/L(ppm)

 

 

Reliable with restrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

 Terrestrial plants ,96-hrEC50 = 4.529 mg/L (ppm)

 Terrestrial plants, 30-day, ChV (chronic value) =2.156 mg/L(ppm)

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Executive summary:

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.

The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Endpoint:
toxicity to terrestrial plants: short-term
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol. Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol .
Qualifier:
no guideline followed
Principles of method if other than guideline:
The inhibition of germination produced by the test compound applied in solution to a seed was determined. Inhibitory activity was expressed as the millimolar concentration of the compound producing 50 per cent inhibition at the given temperature.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Details on preparation and application of test substrate:
The compound was applied in solution to a seed.
Species:
Lactuca sativa
Plant group:
Dicotyledonae (dicots)
Details on test organisms:
Details on test organisms
- Common name: garden lettuce
- Plant family: Asteraceae
- Variety: Great Lakes
- Source of seed: Sutton and Son Ltd.
- Prior seed treatment/sterilization: Not reported
- Historical germination of seed (germination of seed lot tested): Not reported
- Seed storage: Not reported
Test type:
seed germination/root elongation toxicity test
Study type:
laboratory study
Substrate type:
not specified
Limit test:
no
Total exposure duration:
3 d
Test temperature:
30ºC
pH:
not reported
Moisture:
not reported
Details on test conditions:
not reported
Nominal and measured concentrations:
not reported
Species:
Lactuca sativa
Duration:
3 d
Dose descriptor:
EC50
Effect conc.:
2 100 other: mg/l
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
germination
Remarks on result:
other: 95% CL 35 ± 12 mM
Details on results:
EC50 ( 3 d) = 2100 mg/l (inhibition of seed germination)
Validity criteria fulfilled:
not applicable
Conclusions:
A 3 d EC50 of 2100 mg/l has been determined for inhibition of seed germination to Lactuca sativa of the test substance.Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol. Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol .
Executive summary:

A3 d EC50 of 2100mg/l has been determined for inhibition of seed germination to Lactuca sativaof the test substance.  

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamateand n-butanol and propan-2-ol.Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol  and propan-2-ol .

Description of key information

A3 d EC50of2100mg/l has been determined for inhibition of seed germinationto Lactuca sativaof the test substance. 
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamateand n-butanol and propan-2-ol.Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol  and propan-2-ol

Key value for chemical safety assessment

Short-term EC50 or LC50 for terrestrial plants:
2 100 mg/kg soil dw
Long-term EC10, LC10 or NOEC for terrestrial plants:
420 mg/kg soil dw

Additional information

A3 d EC50 of 2100mg/l has been determined for inhibition of seed germination to Lactuca sativa of the test substance. 

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamateand n-butanol and propan-2-ol.Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol  and propan-2-ol