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PBT assessment

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PBT assessment: overall result

Reference
Name:
Reaction mass of propan-2-ol and butan-1-ol and O-isopropyl ethylthiocarbamate
Type of composition:
boundary composition of the substance
State / form:
liquid
Reference substance:
Reaction mass of propan-2-ol and butan-1-ol and O-isopropyl ethylthiocarbamate
Reference substance:
Reaction mass of propan-2-ol and butan-1-ol and O-isopropyl ethylthiocarbamate
Reference substance:
Reaction mass of propan-2-ol and butan-1-ol and O-isopropyl ethylthiocarbamate
PBT status:
the substance is not PBT / vPvB
Justification:

Annex XIII of the REACH Regulation (1907/2006) lays down the criteria for the identification of persistent, bioaccumulative and toxic substances (PBT substances), as well as the information that must be considered for the purpose of assessing the P, B, and T properties of the substance. The criteria require that all available information is to be used, employing a weight-of-evidence approach. Substances must meet all three criteria to be considered PBT.

Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are both reagents used in the manufacture of Reaction mass of O-isopropyl ethyl thiocarbamate and n-butanol and propan-2-ol.Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol)and Butan-1-ol (Butyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethyl thiocarbamate and n-butanol  and propan-2-ol .

The results suggest that Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are readily biodegradable and therefore Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol will be readily biodegradable and it is not expected to persist in the environment.

 

Therefore,Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is not persistent.

 

Bioaccumulation Assessment:

 

Bioaccumulation is considered to be low for Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol which is rapidly metabolised in higher organisms.

 

The estimated Log BCF of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol  and propan-2-ol is 1.86 (BCF = 71.8 L/kg wet-wt).This substance has a limited potential to bioaccumulate (based on log Kow used by BCF estimates: 3.32, and predicted bioconcentration factors, log BCF = 1.86 (EPIWIN/BCF Program).

 

Two evidences result in the conclusion that Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-olis not expected to be B/vB:

 

-The chemical belongs to the thiocarbamate group. In general, thiocarbamates are absorbed via the skin, mucous membranes, respiratory and gastrointestinal tracts, with rapid elimination via expired air and urine.

-Thiocarbamates are also rapidly metabolised, producing either mercapturic acid compounds or compounds that enter the carbon metabolic pool

 

Therefore, Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is not considered to be bioaccumulative.

 

  

Toxicity Assessment:

None of the long-termEC10 orNOECs for marine or freshwater organisms are below 0.01 mg/L. Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is not classified as carcinogenic (Category 1 or 2), mutagenic (Category 1 or 2), or toxic for reproduction (Category 1, 2 or 3). There is no evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC. Therefore Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol does not meet the PBT criteria for toxicity.

 

Summary and overall Conclusions on PBT or vPvB:

Properties Based on the data collected and the discussion above,Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-oldoes not meet the criteria for either PBT or VPvB as it is readily biodegraded in the environment, has a very low bioaccumulation potential, low chronic aquatic toxicity and is not classified as carcinogenic, mutagenic, or toxic for reproduction or for chronic toxicity.