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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Version / remarks:
FCAT (Klecak 1977) and OET (Klecak 1982)
Principles of method if other than guideline:
FCAT (Klecak 1977) and OET (Klecak 1982)
GLP compliance:
no
Remarks:
(publication pre-dates GLP indroduction)
Type of study:
other: The Freund's Complete Adjuvant Test and the Open Epicutaneous Test
Justification for non-LLNA method:
LLNA not available at the time of testing.

Test material

Constituent 1
Chemical structure
Reference substance name:
Linalyl formate
EC Number:
204-120-6
EC Name:
Linalyl formate
Cas Number:
115-99-1
Molecular formula:
C11H18O2
IUPAC Name:
linalyl formate
impurity 1
Chemical structure
Reference substance name:
Linalyl acetate
EC Number:
204-116-4
EC Name:
Linalyl acetate
Cas Number:
115-95-7
Molecular formula:
C12H20O2
IUPAC Name:
1,5-dimethyl-1-vinylhex-4-en-1-yl acetate
impurity 2
Chemical structure
Reference substance name:
Linalool
EC Number:
201-134-4
EC Name:
Linalool
Cas Number:
78-70-6
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethylocta-1,6-dien-3-ol
Test material form:
liquid
Specific details on test material used for the study:
Material: Linalyl Formate

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, open
Vehicle:
other: unspecified
Challenge
Route:
epicutaneous, open
Vehicle:
other: unspecified

Results and discussion

In vivo (non-LLNA)

Results
Group:
test chemical
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Linalyl Formate was tested at 10% and showed no sensitization.