Registration Dossier

Administrative data

Endpoint:
skin sensitisation, other
Remarks:
In silico
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Results and discussion

In vivo (LLNA)

Results
Parameter:
EC3
Value:
11.7
Remarks on result:
other: Database: Skin sensitisaion

Any other information on results incl. tables

Software Method Endpoint Alert Predicted value
ChemProp Enoch et al Skin Sensitisation No Structural Alerts were found. Not active
Toxtree Skin sensitisation reactivity domains Skin Sensitisation No Structural Alerts were found. No alerts

Applicant's summary and conclusion

Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria
Conclusions:
According to (Q)SAR modells: QSAR Toolbox, Toxtree, ChemProp the predicted values indicated that acetoxy-ad-enolether is sensitiser. The result meets the requirement of Hazard Category 1B.