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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
MSDS RHODOCAL®CA/70
Author:
Rhodia
Year:
1998
Bibliographic source:
Product Safety Labs

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium dodecylbenzenesulphonate
EC Number:
247-557-8
EC Name:
Calcium dodecylbenzenesulphonate
Cas Number:
26264-06-2
Molecular formula:
C36H58CaO6S2
IUPAC Name:
calcium dodecylbenzenesulphonate
Details on test material:
(Benzenesulfonic acid, dodecyl-,calcium salt), purity 69-71%.

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100%
Duration of treatment / exposure:
24 hrs
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hrs

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
> 1 - < 3
Remarks on result:
other: May cause serious damage to eyes

Applicant's summary and conclusion

Interpretation of results:
other: irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The test substance is classified as R41, may cause serious damage to eyes, under the DSD.
Executive summary:

Rabbits were exposed to 0.1 ml of 100% test substance in the eye for 24 hrs. Results show that the test substance may cause serious damage to the eyes.